Asqueroso (and asco) come from the Latin eschara, meaning, “scab” (which itself is from the Greek eskhara meaning the same).
From the same Latin (and Greek) root, we also get the English… scar.
So, in Spanish, something that is so disgusting literally scars you!
We can see the mapping in the s-qu-r of asqueroso to the s-c-r of scar.
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